Abstract
The lipid bilayer thickness and the surface area in fluid lyotropic lamellar phases of dipalmitoylphosphatidylcholine (DPPC) containing amphiphilic monohydrochlorides of [2-(alkyloxy)phenyl]-2-(1-piperidinyl)ethyl esters of carbamic acid (CnA, n=number of alkyloxy chain carbons) at DPPC:CnA=1:1 and HO:DPPC≈20:1 molar ratios have been estimated from small angle synchrotron X-ray diffractograms. CnAs intercalate between DPPC molecules resulting in a lateral bilayer expansion and in a decrease of . At the reduced temperature =(-)/=0.035 where is the gel-fluid phase transition temperature, the values of () equal to 3.289±0.012 nm (1.060±0.012 nm), 3.391±0.011 nm (1.055±0.013 nm), 3.403±0.013 nm (1.080±0.012 nm), 3.418±0.012 nm (1.090±0.013 nm) and 3.730±0.012 nm (1.025±0.012 nm) were obtained for C5A, C7A, C9A, C10A and C12A containing phases, respectively. The increase of with increasing n is caused by the decrease in the difference in DPPC acyl and CnA alkyloxy chains lengths. The values of =3.733±0.011 nm and =0.902±0.012 nm obtained for C3A indicate that its location in the phase is different from that of the other CnAs studied. The non-linear dependencies of and on n can contribute to CnAs biological (local anesthetic, antimicrobial, antiphotosynthetic) effects that display similar dependencies on n.
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