Abstract
The kidneys of 54 pairs of twin albino rats, one inoculated and one not inoculated with Walker carcinoma 256, were analyzed for water, total lipid, neutral fat, total fatty acids, total cholesterol, ester cholesterol, free cholesterol, and phospholipid, calculated as gm. per 100 gm. nonlipid dry weight. Compared with the kidneys of their nontumor-bearing littermates, the kidneys of tumor-bearing rats exhibited no significant change in wet weight and in concentration of total lipid, neutral fat, total fatty acids, and ester cholesterol. There was a significant increase in concentration of water, total cholesterol, free cholesterol, and phospholipid. The increase was toward concentrations of corresponding elements in Walker carcinoma 256. The changes became evident in animals bearing tumors weighing 20 to 40% or more of host weight.
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