LIPID AND SILVER NANOPARTICLES GELS FORMULATION OF TEMPEH EXTRACT

Felicia Satya Christania,Rini Dwiastuti,Sri Hartati Yuliani

doi:10.24071/jpsc.002032

Felicia Satya Christania, Rini Dwiastuti + Show 1 more

Open Access

https://doi.org/10.24071/jpsc.002032

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Abstract

Tempeh extract is used in this study as an active ingredient in lipid nanoparticles and reductant in silver nanoparticles because tempeh is an authentic Indonesian food ingredient and is known to have the main content of isoflavones. Gel preparations were chosen to increase the acceptability and stability of lipid and silver nanoparticles. This research is aimed to formulate lipid nanoparticle gel formulations with tempeh extract as active substances and silver nanoparticle gel formulations with tempeh extract as bioreduction. Lipid nanoparticles were made from soy lecithin phospholipids by heating at 600C and sonication method for 30 minutes then the tempeh extract was added just before sonication. Silver nanoparticles were made by adding tempeh extract to the AgNO3 solution at 900C for 30 minutes. The average particle size of tempeh extract lipid nanoparticles was 130.03 nm and silver nanoparticle was 94.76 nm. The average viscosity of tempeh extract lipid nanoparticles gel was 4.02 d.Pa.s and silver nanoparticles was 4.22 d.Pa.s. The average spreadability of tempeh extract lipid nanoparticles gel was 4.37 cm and silver nanoparticles was 4.05 cm. The average pH value of tempeh extract lipid nanoparticles was 7.70 and silver nanoparticles was 7.33.

Highlights

Nanoparticles are one of the technologies developed to increase the effectiveness of drug delivery (Latarissa 2017)
Another method for preparation of nanoparticles is to use metals reduced with specific materials to form nanoparticles, one example is silver nanoparticles using AgNO3 solution added with specific reducing agents (Sileikaite et al 2006)
Instrumentation Instruments used in this study are, particle size analyzer (HORIBA Scientific, Japan), Spectrophotometer UV-VIS (Shimadzu, JAPAN), pH meter, and Viscosimeter Rheosys (Model: Merlin VR)

Summary

Introduction

Nanoparticles are one of the technologies developed to increase the effectiveness of drug delivery (Latarissa 2017). Nano-sized particles have unique physical properties because they can be combined with a variety of technologies. They are expected to produce a more effective drug delivery system (Martien et al 2012). Nanoparticles can be made with specific colloidal formation systems, and one example is liposomes that are made using soy lecithin (Dwiastuti, Noegrohati, and Istyastono 2016). Another method for preparation of nanoparticles is to use metals reduced with specific materials to form nanoparticles, one example is silver nanoparticles using AgNO3 solution added with specific reducing agents (Sileikaite et al 2006)

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