Abstract
Objectives: ATP-binding cassette transporter A1 (ABCA1) plays an essential role in the biogenesis of high-density lipoprotein in the liver and in the prevention of foam cell formation in macrophages by mediating the efflux of cellular cholesterol and phospholipids to apolipoprotein A-I (apoA-I). Previously, we have revealed that the cell surface-resident ABCA1 was ubiquitinated and degraded in lysosome via the Endosomal Sorting Complex Required for Transport (ESCRT) pathway. In order to investigate the relevance of the degradation pathway to lipid disorders, further analyses were conducted.
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