Abstract
A new approach to the asymmetric synthesis of α-substituted serine analogues was developed. The method utilizes a lipase-catalyzed esterification desymmetrization protocol. In the presence of PPL, a series of benzyl-substituted quaternary 2-nitropropane-1,3-diols were successfully desymmetrized by selective acetylation in very good yields and enantioselectivities (up to 95% ee).
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