Abstract
A series of copolymers were prepared by ring-opening polymerization of ɛ-caprolactone and dl-lactide, using zinc lactate as catalyst. The resulting PCL/PLA copolymers were characterized by various analytical techniques such as NMR, SEC, DSC and X-ray diffraction. The [CL]/[LA] ratios of the copolymers are very close to those in the feed, indicating a good conversion of monomers. The copolymers with CL contents higher than 50% appear semi-crystalline, the crystalline structure being of the PCL-type. Compression moulded polymer films were allowed to degrade in a pH = 7.6 phosphate buffer containing Pseudomonas lipase. Data show that copolymers with CL contents lower than 25% are not degradable and the degradation rate increases with CL content for CL-rich copolymers. Various soluble degradation products are detected in the degradation medium, including CL 1 to CL 3 and LA 1 to LA 4 homo-oligomers, and CL 2LA 1 co-oligomer. The presence of LA homo-oligomers and CL 2LA 1 co-oligomer suggests that Pseudomonas lipase can not only degrade PCL but also LA short blocks along PCL/PLA copolymer chains. On the other hand, little changes of composition are detected during degradation, in agreement with a surface erosion mechanism as shown by ESEM.
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