Abstract
Racemic 2-hydroxymethyl-1-iodoferrocene (±)- 1 was subjected to esterification in the presence of lipase from Candida antarctica (Novozym ® 435) to afford (1 S,2 S)-2-acetoxymethyl-1-iodoferrocene (−)- 2 having 89% ee and unreacted (1 R,2 R)-2-hydroxymethyl-1-iodoferrocene (+)- 1 in enantiopure form. A single enantiomer of 2-hydroxymethyl-1-iodoferrocene gave easy access to new ferrocenes and biferrocenes possessing only planar chirality.
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