Abstract
Lipase bio-catalyst or ammonium based deep eutectic mixture efficiently catalyzed aqueous phase synthesis of methyl-thiazole and amino-thiazole derivatives. The simple ammonium deep eutectic catalyst, easily synthesized from choline chloride and urea, is inexpensive, recyclable and bio-degradable, making it suitable for industrial applications. An efficient and eco-friendly process for methyl and amino-thiazole synthesis in aqueous media involving bio-catalyst or ammonium deep eutectic mixtures as catalysts is described. Both the catalysts are bio-degradable, recyclable and non-toxic.
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