Lip creams with propolis special extract GH 2002 0.5% versus aciclovir 5.0% for herpes labialis (vesicular stage) : Randomized, controlled double-blind study.

Jagienka Jautová,Božena Grünwaldová,Hana Zelenková,Katarína Drotarová,Alena Nejdková,Marie Hladiková

doi:10.1007/s10354-018-0667-6

Jagienka Jautová, Božena Grünwaldová + Show 4 more

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https://doi.org/10.1007/s10354-018-0667-6

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Abstract

SummaryA lip cream with special propolis extract GH 2002 at a concentration of 0.5% (199 patients) was tested against aciclovir 5% (198 patients) in the treatment of episodes of herpes labialis under double-blind conditions. Upon inclusion, all patients were in the vesicular phase. Application was five times daily of approximately 0.2 g of cream to the entire upper and lower lip. The primary parameter was the difference in time between groups to complete encrustation or epithelization of the lesions. Secondary endpoints were the course of typical herpes symptoms (pain, burning and itching, tension and swelling), the global assessment of efficacy and the safety of application. The predefined clinical situation was reached after a (median) 3 days with propolis and 4 days with aciclovir (p < 0.0001). Significant differences in favor of propolis were also found for all secondary parameters. No allergic reactions, local irritations or other adverse events occurred.

Highlights

Herpes labialis as a cutaneously manifested viral disease is caused by the herpes simplex virus type 1 (HSV-1), and by the herpes simplex virus type 2 (HSV-2)
The first prodromal symptoms are tingling and itching. They develop into a papular, erythematous phase, which turns into a vesicular phase with virus-containing vesicles, and into an open erosive phase followed by incrustation and healing
With substances of the aciclovir type, whose effect is exclusively based on an antiviral activity [3,4,5,6,7], we found that a truly satisfactory local therapy of the debilitating and painful herpes labialis is not ensured [8, 9]

Summary

Introduction

Herpes labialis as a cutaneously manifested viral disease is caused by the herpes simplex virus type 1 (HSV-1), and by the herpes simplex virus type 2 (HSV-2). The infection manifests itself primarily in the area of the lips, but can broaden into a herpes oticus or herpes ophthalmicus. Stress, solar radiation or immunodeficiency— in old age—the latently present herpes viruses become active and cause the infection process. The first prodromal symptoms are tingling and itching. They develop into a papular, erythematous phase, which turns into a vesicular phase with virus-containing vesicles, and into an open erosive phase followed by incrustation and healing

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