Linked color imaging can improve the visibility of superficial non-ampullary duodenal epithelial tumors

Kenichiro Okimoto,Tatsuya Kaneko,Keiko Saito,Makoto Arai,Jun Kato,Mamoru Tokunaga,Yuki Ohta,Hirotaka Oura,Tomoaki Matsumura,Daisuke Maruoka,Naoki Akizue,Naoya Kato

doi:10.1038/s41598-020-77726-3

Kenichiro Okimoto, Tatsuya Kaneko + Show 10 more

Open Access

https://doi.org/10.1038/s41598-020-77726-3

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Journal: Scientific Reports	Publication Date: Nov 26, 2020
Citations: 3	License type: open-access

Affiliation: Chiba University

Abstract

The current study aimed to evaluate the efficacy of linked color imaging (LCI) in improving the visibility of superficial non-ampullary duodenal epithelial tumors (SNADETs). We prospectively evaluated 44 consecutive patients diagnosed with SNADETs. Three trainees and three experts assessed the visibility scores of white light imaging (WLI), LCI, and blue laser imaging-bright (BLI-b) for SNADETs, which ranged from 1 (not detectable without repeated cautious examination) to 4 (excellent visibility). In addition, the L* a* b* color values and color differences (ΔE*) were evaluated using the CIELAB color space system. For SNADETs, the visibility scores of LCI (3.53 ± 0.59) were significantly higher than those of WLI and BLI-b (2.66 ± 0.79 and 3.41 ± 0.64, respectively). The color differences (ΔE*) between SNADETs and the adjacent normal duodenal mucosa in LCI mode (19.09 ± 8.33) were significantly higher than those in WLI and BLI-b modes (8.67 ± 4.81 and 12.92 ± 7.95, respectively). In addition, the visibility score of SNADETs and the color differences in LCI mode were significantly higher than those in WLI and BLI-b modes regardless of the presence of milk white mucosa (MWM). LCI has potential benefits, and it is considered a promising clinical modality that can increase the visibility of SNADETs regardless of the presence of MWM.This study was registered at the University Hospital Medical Information Network (UMIN000028840).

Highlights

The current study aimed to evaluate the efficacy of linked color imaging (LCI) in improving the visibility of superficial non-ampullary duodenal epithelial tumors (SNADETs)
Regarding the sample size of the patients with SNADETs, the mean color differences (ΔE*) in white light imaging (WLI) and LCI modes were 10.2 and 14.5, respectively, and the response within each subject group had a normal distribution with a standard deviation (SD) of 7.1
To the best of our knowledge, this is the first study that assessed the efficacy of LCI in increasing the visibility of SNADETs using visibility score and color difference

Summary

Introduction

The current study aimed to evaluate the efficacy of linked color imaging (LCI) in improving the visibility of superficial non-ampullary duodenal epithelial tumors (SNADETs). To evaluate the degree of inter-observer agreement for the visibility of SNADETs, the kappa coefficient of reliability was calculated for each subject group in WLI, BLI-b, and LCI. Regarding the sample size of the patients with SNADETs, the mean color differences (ΔE*) in WLI and LCI modes were 10.2 and 14.5, respectively, and the response within each subject group had a normal distribution with a standard deviation (SD) of 7.1.

Results

Conclusion