Linkage of the mouse LDL receptor gene on chromosome 9

Abstract

We identified restriction fragment length variants of the mouse low-density lipoprotein receptor gene and used these to map the gene, designated Ldlr, to the proximal region of chromosome 9. An interspecific backcross between strains MEV and CAST Ei yielded the following gene order and distances in centimorgans: Ldlr-18.8±5.6- Apoa-4-7.3±3.5- Mpi-1-10.2±3.9- Emv-3 or dilute. Analysis of recombinant inbred strains also indicated that Ldlr is tightly linked to a previously unmapped retroviral marker, Xmmv-67.