Linkage of Chemical Changes in Muscle

Abstract

WE should like to report some experiments which form an extension of those recently described by Parnas1, and his colleagues. These workers, using muscle brei poisoned with iodoacetic acid, found that synthesis of creatine phosphate could go on, provided that phosphoglyceric acid was added to the brei. Breakdown of phosphoglyceric acid can only proceed if adenylic acid or adenylpyrophosphate is present, and the synthesis of creatine phosphate was only observed during the short interval of time before the complete deamination of the co-enzyme in the iodoacetic acid brei.