Abstract
It has been suggested that phencyclidine (PCP) receptors may not be linked with N- methyl- d-aspartate (NMDA) receptors in all brain areas. We found that NMDA enhanced [ 3H]TCP (a PCP analog) binding in extensively washed cortical, but not cerebellar membranes. However, PCP potently inhibited NMDA-induced [ 3H]norepinephrine release from cerebellar slices in a concentration-dependent manner, suggesting that a subtype of cerebellar PCP receptors is functionally linked with NMDA receptors. It is suggested that this subtype cannot be demonstrated by [ 3H]TCP binding because of the predominance of low affinity PCP receptors in the cerebellum.
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