Abstract
Introduction: A recent study of the genetic region around the interferon lambda (IFNL) locus revealed the existence of a novel gene named IFNL4. This gene harbors the dinucleotide variant ss469415590 TT>ΔG, which is in high linkage disequilibrium (LD) with IL28B rs12979860 C>T polymorphism. The ss469415590 (ΔG) allele encodes the novel IFNλ4 protein which could be associated with impaired response to Peg-interferon (PEG) and ribavirin (Rbv) therapy.
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