Linkage and haplotype analyses of families with benign adult familial myoclonic epilepsy

Abstract

Background: Benign adult familial myoclonic epilepsy (BAFME) is an autosomal dominant disorder characterized by myoclonic tremor and infrequent epilepsy with a benign clinical course. Several previous studies demonstrated a linkage to 8q24 in Japanese families, whereas families of Italian, French, and Thai origins with similar clinical presentations have been linked to 2p, 5q, and 3q, indicating locus heterogeneity.