Abstract
Primary central nervous system lymphoma (PCNSL) is a rare tumor. It occurs mainly in people aged 50 year-old or older and is more common among men. Immunodeficiency is the only established risk factor for PCNSL. We report a 35 year-old, immunocompetent woman who presented with a two weeks' history of persistent headache. Computed tomography (CT) and magnetic resonance imaging (MRI) showed an expansive lesion in the right thalamus area. Immunohistochemical studies were consistent with the diagnosis of a diffuse large B-cell non-Hodgkin 's lymphoma. The patient was treated with chemotherapy and whole brain radiotherapy, achieving complete remission of the tumor. This case is illustrative of PCNSL and contributes to update its diagnosis, management and prognosis.
Highlights
Primary central nervous system lymphoma (PCNSL) is a rare tumor
La forma clínica de aparición más frecuente es la focalidad neurológica (70%), seguida ción de la agudeza visual del ojo izquierdo y por síntomas neuropsiquiátricos (43%), hipertencefalea holocránea persistente, por lo cual fue sión intracraneana (33%), crisis epilépticas (14%) y hospitalizada
Los esquemas más efectivos son los basados en altas dosis de metotrexato (3,5 g/m2) seguidas de radioterapia holocraneal (estándar 45 Gy), con lo cual se logra una tasa global de respuesta de 94%, una RC de 87% y una sobrevida media de 60 meses[18]
Summary
Primary central nervous system lymphoma (PCNSL) is a rare tumor. It occurs mainly in people aged 50 year-old or older and is more common among men. Se efectuó una resonancia magnética (RM) cerebral que confirmó la lesión expansiva talámica, con significativo edema perilesional y con mínimo efecto de masa sobre las estructuras de la línea media.
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