Linezolid-Resistant Staphylococcus epidermidis, Portugal, 2012.

Mariana Barros,Luísa Peixe,Raquel Branquinho,Filipa Grosso,Carla Novais

doi:10.3201/eid2005.130783

Abstract

Linezolid-Resistant Staphylococcus epidermidis, Portugal, 2012.

Highlights

All S. epidermidis isolates were resistant to multiple drugs, including linezolid (MIC>32 mg/L), cefoxitin, chloramphenicol, cotrimoxazole, ciprofloxacin, clindamycin, and aminoglycosides, and susceptible to only 4 drugs tested, including vancomycin (MIC = 2 mg/L) (Table)
All isolates recovered had the same pulsed-field gel electrophoresis type and belonged to sequence type (ST) 2/clonal complex (CC) 5 (ST2 formerly belonged to CC2) [10] detected among linezolid-resistant S. epidermidis from Europe, Brazil, and the United States [1,2,3]
S. epidermidis from patient 1, considered representative of the observed clone, revealed a high ability to adhere to abiotic surfaces and grow in the biofilm form, which can facilitate infections associated with indwelling medical devices

Summary

Introduction

All isolates recovered had the same pulsed-field gel electrophoresis type and belonged to sequence type (ST) 2/clonal complex (CC) 5 (ST2 formerly belonged to CC2) [10] detected among linezolid-resistant S. epidermidis from Europe, Brazil, and the United States [1,2,3]. S. epidermidis from patient 1, considered representative of the observed clone, revealed a high ability to adhere to abiotic surfaces and grow in the biofilm form, which can facilitate infections associated with indwelling medical devices. S. epidermidis ST2/CC5 is disseminated in hospital settings worldwide and is characterized by a high level of genetic diversity, an increased recombination/mutation rate, biofilm production ability, and acquisition of a high number of staphylococcal cassette chromosome mec elements [10].

Results

Conclusion