Linearized non-equilibrium and non-isothermal two-dimensional model of liquid chromatography for studying thermal effects in cylindrical columns

Abstract

A non-equilibrium and non-isothermal two-dimensional lumped kinetic model (2 D-LKM) is formulated and analytically solved to study the influence of temperature variations along the axial and radial coordinates of a liquid chromatographic column. The model includes convection-diffusion partial differential equations for mass and energy balances in the mobile phase coupled with differential equations for mass and energy in the stationary phase. The solutions are derived analytically through sequential implementation of finite Hankel and Laplace transformations using the Dirichlet inlet boundary conditions. The coupling between the thermal waves and concentration fronts is demonstrated through numerical simulations and important parameters are recognized that influence the column performance. For a more comprehensive study of the considered model, numerical temporal moments are obtained from the derived solutions. Several case studies are conducted and validity ranges of the derived analytical solutions are identified. The current analytical results will play a major role in the improvements of non-equilibrium and non-isothermal liquid chromatographic processes.