Linear rank tests under general alternatives, with application to summary statistics computed from repeated measures data

Abstract

Linear rank tests are used extensively for comparing two or more groups of continuous outcomes. Tests in this class retain proper test size with minimal assumptions and can have high efficiency towards an alternative of interest. In recent years, these tests have been increasingly used in settings where an individual's observation is itself a scalar summary of several outcome measures. Here, simple distributional structures on the outcome variables can lead to complex differences between the distributions of summary statistics of the comparison groups. The local asymptotic power of linear rank tests when the groups are assumed to differ by a location or scale alternative has been studied in detail. However, not much is known about their behavior for other types of alternatives. To address this, we derive the asymptotic distribution of linear rank tests under a general contiguous alternative and then investigate the implications for location–scale families and more general settings, including an example drawn from an AIDS clinical trial where the continuous outcome is a summary statistic computed from repeated measures of a biological marker.