Abstract
Survival analysis is most typically characterized by left truncation; left-truncated data are composed of two recorded times, the time of occurrence of an event before the event of interest, and the time of the interested event. In this study, p-values of the permutation distribution of the linear rank tests are computed using saddlepoint approximation method for left-truncated data using a randomized block design. Simulation studies demonstrate the saddlepoint approximation method’s accuracy in approximating p-value of the linear rank tests. Due to the efficiency of the proposed method over the normal approximation, 95% confidence intervals for the treatment impact are performed.
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