Abstract
Linear immunoglobulin A (IgA) disease, also known as linear IgA bullous dermatosis (LAD), is a rare acquired subepidermal blistering disease characterized by continuous linear IgA deposits in the basement membrane zone (BMZ) when visualized on direct immunofluorescence microscopy (DIF). Linear IgA bullous dermatosis was first described in 1901 by Bowen, who saw 15 children with nonpruritic blistering eruptions mainly involving the genitalia; however, it was not recognized as a entity separate from dermatitis herpetiformes (DH) until 1979. In addition, a druginduced variant of LAD has been recognized in a minority of cases as well as several associations with various infections or chronic illnesses. In LAD, autoantibodies recognize and bind multiple antigens associated with the BMZ, and thus it constitutes a heterogeneous disease with respect to ultrastructural localization of target antigens.
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