Abstract
Due to their proven performance and improved availability, core–shell particles are increasingly applied for chromatographic separations. This paper presents semi-analytical solutions and a moment analysis of a detailed mathematical model for fixed-beds packed with core–shell particles. The model considers axial dispersion, interfacial mass transfer, intraparticle diffusion, linear adsorption, and the injection of rectangular pulses. The Laplace transformation is used as a basic tool to derive semi-analytical solutions. In addition the first three statistical temporal moments are derived from solutions in the Laplace domain. The numerical Laplace inversion is applied for back transformation of the solution in the actual time domain. In order to demonstrate their potential, different scenarios are considered to quantify the effects of the relative core size, axial dispersion, film mass transfer resistance and intraparticle diffusion resistance in the porous layer on the elution profiles. An important new result is the derivation of a plate height equation for fully porous and core–shell particles respecting the Danckwerts boundary conditions.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
