Linear decline of corrected platelet count increment within 24hours after platelet transfusion in haematological patients: A prospective observational study.

Abstract

The aim of this study was to prospectively explore the detailed longitudinal development of platelet increments in patients with chemotherapy-induced bone marrow aplasia during the first 24hours after platelet transfusion. Patients admitted to the Haematology department during 7months, and fulfilled inclusion criteria were divided into 4 groups: Group 1, patients with acute leukaemia; Group 2, patients after autologous stem cell transplantation (SCT); Group 3, patients after allogeneic SCT; and Group 4, patients given platelet transfusion prior to intervention. We used frequent blood sampling within 24hours after platelet transfusion to investigate the kinetics of platelet counts following transfusion. Fifty-four platelet transfusion occasions in patients with chemotherapy-induced bone marrow aplasia were included. The decrease in corrected count increment (CCI) 1-24hours after platelet transfusions in all groups could be described as linear functions. For patients in the aggregated Groups 1-3, the decline was 2.0%±0.6% (mean±standard deviation) per hour. For patients in Group 4, the decline of CCI was 2.8%±1.2% per hour. We found no differences between the groups, either in the rate of platelet elimination from the bloodstream or in the mean CCI, in the first 24hours post-transfusion.