Abstract
The study was conducted on randomly selected 65 type 2 diabetic patients attending the diabetes mellitus center in Al-Sadder Teaching City in Al- Najaf province , Iraq and a group of 24 apparently healthy subjects were included as a control group . The Study was carried out from August 2013 to February 2014.The patients' age was ranging of 35 to 64 years old.The results indicated a significant increase (p<0.05) in serum TSP-1 , Cholesterol, TG,VLDL-C, LDL-C levels and a significant decrease (p>0.05) in serum HDL-C level in diabetic patients in comparing with healthy groups. The results have been shown significant positive correlation (P<0.05) TSP-1 and cholesterol, TSP-1 and TG, TSP-1 and LDL-C, TSP-1 and VLDL-C in DM patients. The results have been shown significant negative correlation (P<0.05) between TSP-1 and HDL-C in type 2 diabetic patients.
Highlights
Diabetes mellitus (DM) is a group of metabolic disorders of carbohydrates metabolism, this condition occurs when inadequate uptake of glucose by the cells of the body causes high levels of glucose in the blood (CDA,2008;,CDA,2013)
The major forms of diabetes are divided into those caused by deficiency of insulin secretion due to pancreatic ß-cell damage, and those that are a consequence of insulin resistance occurring at the level of skeletal muscle, liver, and adipose tissue, with various degrees of ß-cell impairment( Alemzadeh et al.,2008; CDA, 2013)
The present study revealed a significant increase (p
Summary
Diabetes mellitus (DM) is a group of metabolic disorders of carbohydrates metabolism, this condition occurs when inadequate uptake of glucose by the cells of the body causes high levels of glucose in the blood (hyperglycemia) (CDA,2008; ,CDA,2013). Patients with type ІІ diabetes mellitus are insulin resistant, have relatively low insulin production, or both, some patients with type ІІ diabetes may eventually require insulin when other medications fail to control blood glucose levels adequately (Leahy and William, 2002). The major forms of diabetes are divided into those caused by deficiency of insulin secretion due to pancreatic ß-cell damage (type 1 DM), and those that are a consequence of insulin resistance occurring at the level of skeletal muscle, liver, and adipose tissue, with various degrees of ß-cell impairment (type 2 DM)( Alemzadeh et al.,2008; CDA, 2013). Vol 01, No 01, December 2020 wound healing (Bauer et al.,2010; Lopez-Dee et al.,2011)
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