Abstract
Linear correlations have been detected between the photolysis half-lives of polychlorinated dibenzo-p-dioxins (in n-hexadecane solution) and (a) the LD/sub 50/ values (of guinea pigs and chick embryo, r = 0.98) and (b) the relative biological potency values (derived from ED/sub 50/ values, rat hepatoma cell, r = -0.7 to -0.8). These correlations are surprising in view of the wide disparity between a photolysis reaction and a biological end point. It is difficult to avoid considering the possibility of a common or related reactive intermediate in the photolysis reaction and the biological end point. 2 tables.
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