LINEAR ASSESSMENT OF CEREBRAL AUTOREGULATION IN IDIOPATHIC PARKINSON'S DISEASE

Chuang-Chien Chiu,Shoou-Jeng Yeh,Ken Ying-Kai Liao

doi:10.22159/ijpps.2016v8s2.15212

Abstract

<p class="lead">Parkinson’s disease cases have been on the rise in the recent years, which promoted several different researches into the disorder. However, there hasn’t much research been done in the non-motor aspects of the disease. This study aims to improve the understanding of one of the non-motor symptoms of Parkinson’s disease. Specifically, this research aims to further understand cerebral autoregulation in patients with Parkinson’s disease. In order to achieve this aim, 25 subjects were recruited, with 11 healthy controls and 14 patients with Parkinson’s disease. The continuous blood pressure and continuous cerebral blood flow velocity of all subjects were recorded and processed while the subjects were at rest, tilt-up, and during hyperventilation. Linear signal and system analysis techniques were applied such as the power spectral density analysis and cross-correlation function analysis. Results showed that patients with Parkinson’s disease did not show a significant difference from the control group while at rest and after tilt-up. However, there was a significant difference between the groups during hyperventilation. The results obtained in this study suggested that the metabolic regulatory pathway for cerebral autoregulation is impaired in patients with Parkinson’s disease.</p>

Highlights

Parkinson's disease (PD) is a neurodegenerative disorder which is generally known to affect movement
Both the mean blood pressure (MBP) and mean cerebral blood flow velocity (MCBFV) signals were averaged to find the mean of each signal to see whether or not a significant difference existed for when the subjects were at rest, tilt, or hyper
From the results shown in table 1, ANOVA showed no significant differences between the subject groups in any of the stimulations or any of the signals

Summary

Introduction

Parkinson's disease (PD) is a neurodegenerative disorder which is generally known to affect movement. It was first described by James Parkinson in 1817 as the shaking palsy. Fox. With PD becoming more and more prevalent, more and more research has been poured into understanding the mechanisms of how PD works, as well as the motor symptoms of PD. With PD becoming more and more prevalent, more and more research has been poured into understanding the mechanisms of how PD works, as well as the motor symptoms of PD It wasn't until recently that non-motor symptoms of PD became an interest to researchers [1]

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