Linear and Nonlinear Heart Rate Variability Analysis in Gonadal Dysgenesis (Swyer Syndrome): A Case Report

Valdelias Xavier Pereira,Alex Rey Norberto,Marcos Antonio Marinovic,Tatiana Dias De Carvalho,Isabel Cristina Esposito Sorpreso,José Maria Soares,Vitor Engrácia Valenti

doi:10.36660/ijcs.20200002

Abstract

Swyer syndrome is one of the disorders of sexual differentiation. Previous studies have demonstrated increased sympathetic activity with heart rate variability (HRV) analysis with decreasing estradiol levels. One patient presented a pure 46, XY gonadal dysgenesis with female phenotype. Cardiac autonomic modulation was assessed through HRV analysis while at rest. This research analyzed linear and nonlinear indexes. HRV analysis showed reduced parasympathetic and global modulation with an apparent increase in sympathetic tone and a loss of HR fractal dynamics [...]

Highlights

Swyer syndrome is one of the disorders of sexual differentiation (DSD), a pure gonadal dysgenesis with karyotype 46, XY, the presence of two digenetic gonads or gonads streak. and devoid of germinative elements
This study reports on the autonomic behavior of heart rate variability (HRV) in Swyer Syndrome, but the report exempts itself from an in-depth review
Cardiac autonomic modulation was assessed through HRV analysis

Summary

Introduction

Swyer syndrome is one of the disorders of sexual differentiation (DSD), a pure gonadal dysgenesis with karyotype 46, XY, the presence of two digenetic gonads or gonads streak. and devoid of germinative elements. Swyer syndrome is one of the disorders of sexual differentiation (DSD), a pure gonadal dysgenesis with karyotype 46, XY, the presence of two digenetic gonads or gonads streak. The clinical presentations are female phenotype with typical female external genitalia, primary amenorrhea and persistent hypergonadotropic hypogonadism, normal stature, and absence of somatic malformations.[1]. Previous studies have demonstrated increased sympathetic activity with heart rate variability (HRV). The clinical and therapeutic implication of autonomic impairment is still unclear.[1] This study reports on the autonomic behavior of HRV in Swyer Syndrome, but the report exempts itself from an in-depth review.

Methods

Discussion

Conclusion