Lineage does not regulate the sensory synaptic input of projection neurons in the mouse olfactory bulb.

Luis Sánchez-Guardado,Carlos Lois

doi:10.7554/elife.46675

Abstract

Lineage regulates the synaptic connections between neurons in some regions of the invertebrate nervous system. In mammals, recent experiments suggest that cell lineage determines the connectivity of pyramidal neurons in the neocortex, but the functional relevance of this phenomenon and whether it occurs in other neuronal types remains controversial. We investigated whether lineage plays a role in the connectivity of mitral and tufted cells, the projection neurons in the mouse olfactory bulb. We used transgenic mice to sparsely label neuronal progenitors and observed that clonally related neurons receive synaptic input from olfactory sensory neurons expressing different olfactory receptors. These results indicate that lineage does not determine the connectivity between olfactory sensory neurons and olfactory bulb projection neurons.

Highlights

The relationship between cell lineage and neuronal connectivity in the brain is not well understood.nervous system
In the Drosophila olfactory system, projection neurons are specified by cell lineage to receive synaptic input from the axons of specific types of olfactory sensory neurons (OSNs) (Jefferis et al, 2001; Li et al, 2018)
The mammalian olfactory system can be divided into three regions: olfactory epithelium, olfactory bulb (OB) and olfactory cortex

Summary

Introduction

The relationship between cell lineage and neuronal connectivity in the brain is not well understood.nervous system. Cells progenitors and investigated the sensory input that their progeny receives from OSNs. Our results show that sister M/T cells receive synaptic input from different glomeruli, indicating that lineage does not determine the neuronal connectivity of the OB projections neurons, and suggest that the assembly of the OB mostly depends on non-genetic mechanisms.

Results

Conclusion