Abstract
Feeding of male Wistar rats for 8 days with a diet containing 250 ppm of lindane resulted in a maximal accumulation of the xenobiotic in kidney followed by adipose tissue, liver, brain, and lung. These tissues were isolated from control and lindane-intoxicated rat for quantitative analysis of major phospholipids using thin-layer chromatography and gas chromatography. In lindanetreated rats, the total phospholipid amount was augmented but choline glycerophospholipids and ethanolamine glycerophospholipids were not equally increased so that the choline glycerophospholipids/ethanolamine glycerophospholipids ratio was different from that in the control group. Despite differences in the phospholipids content, the composition of phospholipid fatty acids was similar in the two groups of rats. The results suggest a relationship between accumulation of lindane and increase of phospholipid amounts in the rat tissues.
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