Abstract
Long intergenic non-coding RNA 01,087 (LINC01087) has been concerned as an oncogene in breast cancer, while its mechanism in glioma has been little surveyed. Thus, we searched the prognostic value and functional action of LINC01087 in glioma. Glioma patients after preoperative MRI diagnosis were enrolled, and LINC01087, microRNA (miR)-1277-5p, and alkaline ceramidase 3 (ACER3) levels were tested in glioma cancer tissue. The correlation between LINC01087 expression and the survival of patients were analyzed. LINC01087, miR-1277-5p, and ACER3 levels in U251 cells were altered via transfection, and cell malignant phenotypes were monitored. The relationship between miR-1277-5p and LINC01087 or ACER3 was detected. The LINC01087 and ACER3 expression was in up-regulation and the miR-1277-5p expression was in down-regulation in clinical glioma samples. High expression of LINC01087 was associated with poor prognosis of glioma patients with preoperative MRI. LINC01087 silencing restrained tumor malignancy in glioma cells. Mechanistically, LINC01087 directly interacted with miR-1277-5p. ACER3 was a known target of miR-1277-5p. Moreover, rescue assays reveal that miR-1277-5p overexpression (or ACER3 overexpression) reversed the effects of LINC01087 upregulation (or miR-1277-5p upregulation) on glioma cells. LINC01087 has prognostic significance in glioma and silencing LINC01087 deters glioma development through elevating miR-1277-5p to reduce ACER3 expression.
Highlights
Gliomas are intrinsic intracranial tumors derived from glial progenitor cells, of which glioblastoma is the most malignant form and of ill repute for treatment resistance (Gusyatiner and Hegi 2018)
We examined the prognostic value of LINC01087 in glioma and explored whether LINC01087/miR-1277-5p/alkaline ceramidase 3 (ACER3) axis could modulate the biological activities of glioma cells
Increased LINC01087 in glioma patients is associated with poor prognosis
Summary
Gliomas are intrinsic intracranial tumors derived from glial progenitor cells, of which glioblastoma is the most malignant form and of ill repute for treatment resistance (Gusyatiner and Hegi 2018). Genetic factors, ionizing radiation, and history of allergies are generally considered to be known risk factors (Davis 2018). The survival rates differ among all LncRNA is a functional RNA molecule that participates in glioma, and lncRNA-regulated miRNA and signaling pathways offer a prospect of developing therapies for glioma (Dang et al 2018). Xuan Wang et al have proposed that targeted-depletion of LINC00473 deters glioma progression via interacting with miR-195-5p (Wang et al 2020). Shi J et al announce that a cellular therapy based on LINC00174/ miR-152-3p interaction could regulate glycolysis and tumorigenicity in glioma (Shi et al 2019). Liu X et al have illustrated the promoting effects of LINC00689
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
