Abstract
Long intergenic non-coding RNA 00839 (LINC00839) has been verified as a pro-metastasis factor in malignancies. However, the significance of LINC00839 in nasopharyngeal carcinoma (NPC) has yet to be illuminated, as well as its underlying mechanism. Here, we disclosed that LINC00839 is highly expressed in NPC. Deletion of LINC00839 suppresses NPC cells rapid growth, invasive capacity and EMT in vitro. Besides, LINC00839 is identified as a “sponge” for miR-454-3p, and upregulation of LINC00839 reverses miR-454-3p-mediated inhibition of aggressiveness in NPC cells. Furthermore, the expression of cellular-mesenchymal epithelial transition factor (c-Met), the downstream target of miR-454-3p, is downregulated by LINC00839 knockdown in NPC cells. In vivo, LINC00839 knockdown retards the tumor growth of NPC cells in the xenografted mice model. Collectively, attenuation of LINC00839 expression attenuates the aggressive properties of NPC cells via directly sponging the miR-454-3p and regulating c-Met expression.
Highlights
Nasopharyngeal carcinoma (NPC), which derives from nasopharyngeal epithelial cell, is a frequent subtype of head and neck cancer [1]
These results demonstrate LINC00839 is upregulated in NPC and LINC00839 knockdown inhibits NPC cells growth in vitro
LINC00839 acts as an oncogenic gene and is significantly upregulated in human cancers including breast cancer and osteosarcoma [11, 12]
Summary
Nasopharyngeal carcinoma (NPC), which derives from nasopharyngeal epithelial cell, is a frequent subtype of head and neck cancer [1]. Due to patients with NPC usually with no specific symptoms in the early stage, most of them have stepped into advanced stages when diagnosed. As for the treatment, radiotherapy is the backbone of therapy for NPC and concurrent chemoradiotherapy has become the therapeutic option for the advanced NPC [2]. The five-year overall survival of patients with NPC has increased to about 70% [3]. A complete cure of metastatic NPC remains elusive owing to its local recurrence and metastasis. The mechanism underlying NPC progression, including metastasis has not been completely understood yet
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