Abstract
Long intergenic non-protein coding RNA, regulator of reprogramming (linc-ROR) is an intergenic long non-coding RNA (lncRNA) previously shown to contribute to tumorigenesis in several malignancies. However, little is known about whether linc-ROR has a role in ovarian cancer progression. In this study, we found that linc-ROR expression was increased in high-grade ovarian serous cancer tissues compared with normal ovarian tissues or normal fallopian tube tissues. Furthermore, the level of linc-ROR expression was associated with ovarian cancer International Federation of Gynecology and Obstetrics stage and lymph node metastasis. Linc-ROR promoted ovarian cancer cell proliferation both in vitro and in vivo, and contributed to cell migration and invasion. Linc-ROR knockdown in ovarian cancer cell lines inhibited the epithelial-to-mesenchymal transition (EMT) program, which led to ovarian cancer cell metastasis through the repression of canonical Wnt/β-catenin signaling. Together, our results indicated that linc-ROR induces EMT in ovarian cancer cells and may be an important molecule in the invasion and metastasis of ovarian cancer.
Highlights
Ovarian cancer has the highest mortality rate among all gynecological malignancies
We demonstrate that the linc-ROR-induced changes in epithelial-to-mesenchymal transition (EMT) in ovarian cancer cell lines are the result of alterations in the canonical Wnt/β-catenin signaling pathway
After small interference RNA (siRNA) transfection, linc-ROR expression was significantly lower in the si-linc-ROR groups than in the si-negative control (NC) group (Figure 2A, P
Summary
Ovarian cancer has the highest mortality rate among all gynecological malignancies. Compared with early ovarian cancer, patients who are diagnosed with advanced ovarian cancer are more likely to have invasion and peritoneal metastasis to adjacent organs [1, 2]. Highgrade ovarian serous cancer is a common type of ovarian cancer that is highly malignant and has an aggressive capacity; most affected patients die from their metastases [3]. Previous studies have indicated that the epithelialto-mesenchymal transition (EMT) is closely related to the invasion and metastasis of ovarian cancer [4]. The EMT program provides the molecular basis for the invasion and metastasis of epithelial tumor cells, and is a critical event in the early stages of invasion and metastasis of malignant tumors [5]
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