Abstract
DOI of original article: 10.1016/j.jss.2012.1 * Corresponding author. Department of Surg Tel.: þ1 513 558 8467; fax: þ1 513 558 3474. E-mail address: prittsta@ucmail.uc.edu (T 0022-4804/$ e see front matter a 2013 Elsev http://dx.doi.org/10.1016/j.jss.2013.02.014 Proinflammatory states are widely implicated in both acute and chronic disease processes. Severe acute systemic inflammation is at least partially responsible for shock and acute lung injury, and therapeutic options to curb the proinflammatory responses are limited. Sustained release of proinflammatory mediators by macrophages and other leukocyte subtypes is the hallmark of autoimmune illnesses. In addition to nonspecific immunosuppressants, targeted therapies to reduce inflammation via inhibition of cytokine release are available for some of these illnesses, including Crohn disease and rheumatoid arthritis. However, the subsequent risk of infection with these medications is significant, which limits their clinical use. Linalool is a terpene alcohol that occurs naturally in several edible plant species. It is used in soaps, oils, and other topical products, but has not been evaluated previously as a therapeutic. Its role as an inflammatory mediator is unknown. Based on the antimicrobial and anxiolytic properties of
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