Limonoids from the Seeds of Chisocheton macrophyllus

Abstract

A new limonoid compound, dysobinol (1), along with three known limonoid compounds, 7α-hydroxyneotricilenone (2), dysobinin (3), and nimonol (4), was isolated from the seeds of Chisocheton macrophyllus (Meliaceae). Their structures were established by spectroscopic techniques such as UV, IR, MS, 1D, and 2D NMR. Compounds 1–4 showed cytotoxic activity against P-388 murine leukemia cells with IC50 values of 49.7, 79.4, 19.5, and 64.5 μg/mL, respectively.