Limiting the Current Density During Localization of the Primary Motor Cortex by Using a Tangential-Radial Cortical Somatosensory Evoked Potentials Model, Direct Electrical Cortical Stimulation, and Electrocorticography

Abstract

Traditionally, the dual-radial model, which requires high cortical stimulation intensities and may evoke intraoperative seizures, is used for mapping during resection of lesions within or near the central sulcus. To examine the potential utility of using the multimodal tangential-radial triphasic model, which may increase the accuracy and reliability of cortical mapping at lower stimulation intensities. We performed a retrospective review of intracranial neuromonitoring cases at the University of Virginia. The tangential-radial triphasic model used direct electrical cortical stimulation (DECS), electrocorticography, and somatosensory evoked potentials with an additional P25 peak for waveform interpretation, instead of the older dual-radial model with N20 and P30 peaks alone. The central sulcus and sensory cortex were localized by generating multiple sensory maps. DECS with 50-Hz frequency was applied. Electrocorticography was used for detection of afterdischarges. Fifteen consecutive intracranial cases were identified. The patients consisted of 8 males and 7 females ranging in age from 12 to 74 years (median, 53 years). Fourteen patients had an intra-axial cortical mass, and 1 patient had a cortical arteriovenous malformation. The DECS thresholds ranged from 3.7 to 12 mA (median, 6.2 mA). Localization of motor and sensory cortices was accurately performed at low thresholds with bipolar DECS in all patients. Intraoperative seizures occurred in 1 patient (7%), and new permanent postoperative functional deficits occurred in 1 patient (7%). Our mapping technique appears safe and reliable for resection near the central sulcus. The tangential-radial triphasic model allows for lower stimulation intensities, reducing the risk of intraoperative seizures.