Limiting blood transfusion during anhepatic state to improve blood stasis of the portal vein system in piggback orthotopic liver transplantation

Abstract

Objective To investigate the effect of blood transfusion on blood stasis of the pottal vein system during anhepatic state in piggback orthotopic liver transplantation(PBOLT).Methods Sixteen cases undergoing PBOLT were equally divided into two group:uncontrolled blood transfusion group(group A)and controlled blood transfusion group(group B).During pre-anhepatic,anhepatic and neohepatic states,mean artery pressure(MAP),central vein pressure(CVP),heart rate(HR),liver function test (LFT)and hydrolytes were observed and the degree of the gastrointestinal tract gore was examined.Results There was no significant difference in CVP and HR between group A and group B during preanhepatic state(P>0.05),but MAP in group A was significantly lower than that in group B(P<0.05).MAP,CVP and HR were significantly lower in group A than those in group B(P<0.01).The concentration of blood K+was obviously higher in group A than in group B(P<0.05),while carbon dioxide combining power(CO2CP)Was obviously lower in group A than in group B(P<0.05).Conclusions Controlled blood transfusion and liquid transfusion might be an effective method to reduce gore of the portal vein system and maintain hemodynamics steady during anhepatic state in PBOLT. Key words: Liver transplantation; Portal vein; Hemodynamics; Swine