Abstract
Proton-pump inhibitors (PPIs) have revolutionized our approach to both the diagnosis and treatment of gastroesophageal reflux disease (GERD). Although a trial of empirical PPI therapy has become standard for patients with suspected GERD or related extraesophageal complications, an emerging subset of patients are nonresponders. In this retrospective analysis, researchers examined the value of pH monitoring in 250 symptomatic patients at Cleveland Clinic who underwent pH monitoring while taking a PPI (once or twice daily). Normal pH values were defined according …
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