Abstract
Several studies have indicated that diet and exercise may modulate the gut microbiota in obese subjects. Both interventions were shown to alter the microbiota orthogonally. However, this relationship has not been fully explored. This study analyzed the effects of low-to-moderate aerobic training on the fecal microbiota of mice subjected to a high-fat diet (HFD). Here, 40 male mice (C57Bl/6) were divided into two groups with standard diet (SD; 12.4% lipid) and HFD (60.3% lipid) for four months. These groups were divided into four, named SD control, HF control, SD trained and HF trained. All animals were submitted to an incremental test to estimate low-to-moderate maximum speed. Training consisted of 30 min·day−1, 5 days/week, for 8 weeks. The HFD increased the body weight (p < 0.0001) and adiposity index (p < 0.05). HFD also negatively influenced performance in exercise training. Moreover, the diversity of gut microbiota was reduced by the HFD in all groups. A low-to-moderate exercise was ineffective in modulating the gut microbiota composition in mice subjected to HFD. These findings suggest that two months of low-to-moderate exercise does not achieve a preponderant modulatory effect on shaping microbiota when submitted to the high-fat diet.
Highlights
Obesity is one of the most impactful chronic nontransmissible diseases in the world [1]
Effect of High-Fat Diet and Low-to-Moderate Exercise on Body Weight, Adiposity, Food Intake and a significant weight gain was observed in the animals fed with high-fat diet (HFD) when compared to those fed with
During the diet administration, a significant difference from the second month of ongoing diet (p < 0.0001), being represented by the a significant weight gain was observed in the animals fed with HFD when compared to those fed letter “a”with
Summary
Obesity is one of the most impactful chronic nontransmissible diseases in the world [1]. About 13% of adults are obese, and 39% are considered to be overweight worldwide [2]. The obesity pandemic has resulted in high public health expenditure [3] and a high death rate worldwide [4]. Due to the high pathogenesis complexity, significant efforts are being made by public health policies and scientific research to establish novel strategies in its prevention and treatment [5]. Studies have shown that the gut microbiota plays a significant role in the pathogenesis of obesity [6], where the positive regulation within its content may be used as a clinical treatment [7,8,9].
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