Abstract
Dynamic tissue perfusion measurement (DTPM) is a pre-described and available method in pediatric ultrasound to quantify tissue perfusion in renal Doppler ultrasound by particular video analysis software. This study evaluates DTPM during single and between repeated visits after 6 months, calibrates repeated DTPM within different region of interest (ROI) and compares DTPM with kidney function markers in adult patients with early diabetic nephropathy (n = 17). During repeated measurements, no association of readings at the same patients in the same (n = 3 readings) as well as repeated visit (n = 2 visits) could be retrieved. No association between DTPM, MDRD-GFR, albuminuria, age and duration of diabetes was observed. These negative results are presumably related to inconsistency of DTPM due to non-fixed ROI position as could be shown in calibrating series. Further development of the method should be performed to enable reproducible DTPM readings in adults.
Highlights
Assessment of renal function and early diagnosis of chronic kidney disease (CKD) requires sensitive and robust tools to characterize excretory kidney function, albuminuria, and structural organ changes
The study was approved by the Ethical Review Board (ERB) of the Saxonian Association of Physicians, Dresden, Germany (# EK-BR 88/13-1)
To calibrate the variability of total perfusion depending on the positioning of region of interest (ROI) we examined three healthy subjects with different approaches of positioning
Summary
Assessment of renal function and early diagnosis of chronic kidney disease (CKD) requires sensitive and robust tools to characterize excretory kidney function, albuminuria, and structural organ changes. Beside contrast enhanced sonography [1], dynamic tissue perfusion measurement (DTPM) by a colour-pixel quantifying picture analysis (Pixelflux, Germany) was introduced and has demonstrated the potential to describe perfusion in renal cortex in children kidneys, children transplants and other organs. These authors described correlations between perfusion quantitative measures and renal transplant function. These measurements were done in yearly subsequent investigations of paediatric renal graft recipients without standardized data concerning repeatability during the same visit [2, 3]. A huge DTPM difference was displayed between the overall cohort during year 1 and 5 (0.4cm/sec) and a subset of patients
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