Abstract
The intestinal epithelium is a highly proliferative tissue with robust regenerative potential, governed by the intestinal stem cell (ISC) compartment. Our understanding of the cellular hierarchy within this compartment is drawn from Cre-lox–based lineage tracing studies, initially via the identification of crypt base columnar stem cells (CBCs) using an Lgr5eGFP-IRES-CreER allele and the R26LSL-LacZ reporter,1 showing that CBCs reconstitute all epithelial cell types during homeostasis.2 Despite their proliferative capacity, CBCs are exquisitely sensitive to injury, requiring facultative stem cells for postinjury regeneration.
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