Abstract

In recent years, the difference or bias plot for evaluation of method comparison data has become increasingly popular. Originally suggested by Bland and Altman for comparison of measurements in clinical medicine, the procedure also has been adopted in clinical chemistry (1)(2)(3). The difference plot is very instructive for the display of differences as functions of the measurement average. In addition to the graphical display, however, it is usual to present some form of summary statistics for a method comparison study. In association with the difference plot, the paired t -test is usually applied (1). The paired t- test is ideal for evaluation …

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