Abstract
Human chorionic gonadotropin (hCG) has been recognised as a valuable marker of pregnancy and trophoblastic tumours since the late 1920s. 1 Zondek B Hypophysenvorderlappen und Schwangerschaft. Endocrinologie. 1929; 5: 425-434 Google Scholar Bioassays employing a remarkable variety of species were replaced by immunoassays in the 1960s and evolved through haemagglutination inhibition, competitive binding radioimmunoassay, 2 Wilde CE Orr AH Bagshawe KD A radioimmunoassay for human chorionic gonadotrophin. Nature. 1965; 205: 191-192 Crossref PubMed Scopus (26) Google Scholar and immunometric assay. The last of this lends itself readily to assay kits now available from several manufacturers. False diagnosis and needless therapy of presumed malignant disease in women with false-positive human chorionic gonadotropin concentrationsCurrent protocols for the diagnosis and treatment of choriocarcinoma should be modified to include a compulsory test for hCG in urine. Full-Text PDF
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