Liminal and supraliminal response characteristics of mechanoreceptive neurons in the cuneate nucleus of cat.

Abstract

The response characteristics of mechanoreceptive neurons (RA, SA, and PC) innervating the foot pad of cat were determined in the cuneate nucleus. The mechanical stimuli were single sinusoidal pulses of varying frequency (20, 60, 150, and 240 Hz), and vibratory trains of varying frequency (80 and 240 Hz) and duration (50, 100, and 400 ms). Thresholds and stimulus-response functions were determined with single pulses. Absolute thresholds (1 impulse/train), tuning thresholds (1 impulse/cycle), and atonal intervals (the range between absolute and tuning thresholds) were determined with vibratory stimulus trains. When tested with single pulses the thresholds resembled those of primary afferents in all unit populations. The stimulus-response function of PC units but not of all RA units were comparable to those of primary afferents. Noxious conditioning stimulation did not influence the thresholds of cuneate mechanoreceptors in the tested sample (N = 6). Mostly PC units were tested with vibratory trains. Absolute thresholds were not dependent on stimulus duration, which is a consistent finding with peripheral units. In contrast to peripheral units, the tuning thresholds in most PC units were elevated with increasing stimulus duration. The variability in the range of atonal intervals was much larger than in the periphery. Thus, it seems that both the type of the tactile signal and the type of the studied mechanoreceptive neuron are critical parameters in determining whether the response characteristics of neurons in the cuneate and in the periphery are identical or not.