Abstract
IntroductionVery little is known about the influence of early-onset infections and perinatal complications on CD4+/CD25+ lymphocytes in prematures. AimAssessment of the percentage and number of CD4+/CD25+ in prematures, including their sex, birth asphyxia, kind of early-onset infection and mode of delivery. Material and methodThe study comprised 50 prematures born between 26-37 week of gestation, among them 27 infected (sepsis – 15, pneumonia – 12) and 23 without infection. The immunological examination comprised once determination of leukocytes, lymphocytes, CD3+, CD4+ and CD25+ in peripheral vein blood using FACS scan flow cytometer and mononuclear antibodies from Becton Dickinson. ResultsThe mean percentage and mean number of CD4+/CD25+ in infected prematures were significantly higher than in babies without infection. Male infected prematures had significantly higher values of CD4+/CD25+ than boys without infection. Any correlation between CD4+/CD25+ values and Apgar score and mode of delivery was noted. Conclusions1. Severe early-onset infection, independently of their kind, increase the percentage and number of CD4+/CD25+ in prematures. Estimate of CD4+/CD25+ may be a marker of early-onset infection, especially in cases with negative results of bacteriological findings. 2. Birth asphyxia and nonphysiological delivery had any influence of quantitive changes of CD4+/CD25+ in prematures.
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