Limbs move beyond the Radical fringe

Abstract

Zhang and Gridley reply — We too have created mice that have a large deletion in the Radical fringe gene and investigated the resulting effect on their development. Our results agree with those of Moran in showing that Rfng is not an essential gene in mice, but they do not support the idea that the presence of a neo- selection cassette inserted into the Rfng locus invariably leads to embryonic lethality.