Abstract
Statistical comparisons of means in groups of morphine-dependent (or post-dependent) rats with and without bilteral lesions in the cingulum, the dorsomedial thalamic nucleus, the anterior temporal lobe (amygdaloid complex and ventral hippocampus), or the septum, and in nondependent rats with and without such lesions, revealed no significant lesion effects on specific signs of the 24-hr primary morphine-abstinence syndrome in this species: decreased water intake; increased “no-choice” drinking of a 5-μg/ml aqueous solution of a potent opioid (etonitazene); increased “wet dog” shake frequency; fall in colonic temperature. Lesions in the cingulum attenuated one sign of the secondary (protracted) morphine-abstinence syndrome (increased 24-hr water consumption). None of the lesions altered the suppressive effects on the primary morphine-abstinence syndrome of “no-choice” etonitazene-drinking or of intraperitoneal injection of morphine. None of the lesions prevented “relapse” of postdependent rats, as measured by comparisons of mean volumes of etonitazene (5-μg/ml) and water consumed in “choice” trials 9–72 days after permanent withdrawal of morphine.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
