Abstract
Limbic encephalitis is a rare paraneoplastic neurological syndrome usually associated with small cell lung cancers, testicular and breast cancers or B-cell lymphomas. We herein report the first patients with paraneoplastic limbic encephalitis associated with HU antibodies and anaplastic T-cell lymphoma.
Highlights
Paraneoplastic neurological syndromes (PNS) are rare neurological disorders occurring in less than 1% of people, with malignancy not due to direct tumor infiltration or metastases, infection, ischemia, metabolic or nutritional deficits, nor chemotherapy side effects [1,2]
PNS are rarely associated with B-cell lymphomas, with paraneoplastic cerebellar degeneration being the most common neurological manifestation
To the best of our knowledge, this is the first reported patient with limbic encephalitis associated with the HU antibody, known as Anti-ANNA1-associated encephalitis, in a T-cell lymphoma [3]
Summary
Paraneoplastic neurological syndromes (PNS) are rare neurological disorders occurring in less than 1% of people, with malignancy not due to direct tumor infiltration or metastases, infection, ischemia, metabolic or nutritional deficits, nor chemotherapy side effects [1,2]. Hematological malignancies are rarely associated with PNS [3,4]. The most common PNS was paraneoplastic cerebellar degeneration, often associated with anti-Tr antibodies. Limbic encephalitis has been described in lymphomas, with antibodies to. The metabotropic glutamate receptor 5 (mGluR5) has been identified as another target antigen in limbic encephalitis in HL, known as Ophelia syndrome. We report on the first patient with limbic encephalitis and HU antibodies, known as Anti-ANNA1-associated encephalitis, in a T-cell anaplastic lymphoma [5].
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