Abstract
It is a well-established fact that peripheral nerves, if they are to remain in a proper functional state, require a continuous and adequate supply of oxygen. 1-4 As a consequence, temporary or permanent interference with the microcirculation of peripheral nerves might be expected to disturb nerve function. Ischemia to extremities can occur in various situations: routine surgical procedures performed in a blood-free field under the influence of a pneumatic cuff; trauma involving injury to major vessels. An experimental study was designed to analyze the pathophysiologic mechanisms in the development of nerve lesions after prolonged ischemia. 5 In anesthetized rabbits, ischemia for various periods was induced by a pneumatic cuff around the hind leg. In the postischemic phase the restitution of intraneural microvascular flow was determined with a microscopic technique, allowing analysis of blood flow patterns in the living animal. Ischemic injury to the vessel walls resulting in increased permeability was
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