LIM-Kinase1 and CREB regulation of synaptic plasticity and memory

Abstract

Event Abstract Back to Event LIM-Kinase1 and CREB regulation of synaptic plasticity and memory Zarko Todorovski1, 2* and Zhengping Jia1, 2 1 University of Toronto, Department of Physiology, Canada 2 The Hospital for Sick Children, Neurosciences and Mental Health, Canada Regulation of neuronal structural plasticity is known to be important for learning and memory. LIM-Kinase 1 (LIMK1) is an important regulator of postsynaptic structural morphology by its regulation of actin dynamics by regulating the activity of actin depolymerizing factor (ADF)/cofilin. Previous studies from our lab have shown that LIMK1 knockout mice exhibit abnormal dendritic spine morphology as well as altered hippocampal early long-term potentiation (E-LTP). In addition, a recent study has found that LIMK1 can directly interact with and phosphorylate CREB in hippocampal neuroprogenitor cells. CREB is an important and well-studied transcription factor that facilitates the changes from short-term memory to long-term memory. CREB activation is also known to be important in late long-term potentiation (L-LTP). Based on this evidence we proposed that LIMK1 might play a role in long-term memory and long-term synaptic plasticity via regulation of CREB in mature hippocampal neurons. Accordingly, we have shown that LIMK1 exists in an immunocomplex with CREB in mature hippocampal slices. Moreover, mice lacking LIMK1 were shown to be deficient in L-LTP induced by high frequency stimulation, and L-LTP induced by strong theta burst stimulation. This evidence suggests a role for LIMK1 in L-LTP and long-term synaptic plasticity via regulation of CREB. In addition, mice lacking LIMK1 did not perform as well in fear conditioning tests. LIMK1 knockout mice exhibited less freezing than wild-type littermate controls in the contextual memory test. These results suggest that LIMK1 plays a role in long-term memory. Taken together, these results are indicative of a role for LIMK1 in a long-term memory and long-term synaptic plasticity via regulation of CREB. Conference: B.R.A.I.N. platform in Physiology poster day 2009, Toronto, ON, Canada, 16 Dec - 16 Dec, 2009. Presentation Type: Poster Presentation Topic: Poster presentations Citation: Todorovski Z and Jia Z (2009). LIM-Kinase1 and CREB regulation of synaptic plasticity and memory. Front. Neurosci. Conference Abstract: B.R.A.I.N. platform in Physiology poster day 2009. doi: 10.3389/conf.neuro.03.2009.17.046 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 18 Dec 2009; Published Online: 18 Dec 2009. * Correspondence: Zarko Todorovski, University of Toronto, Department of Physiology, Toronto, Canada, zarko.todorovski@utoronto.ca Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Zarko Todorovski Zhengping Jia Google Zarko Todorovski Zhengping Jia Google Scholar Zarko Todorovski Zhengping Jia PubMed Zarko Todorovski Zhengping Jia Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.