Abstract
The diagnosis of food allergy is challenging due to different immunologic mechanisms and diversity of symptoms. An open or double-blinded oral food challenge (OFC) was performed on 391 children (aged 0.2–16.9 years) with suspected cow's milk (n = 266) or wheat allergy (n = 125) to characterize immediate, delayed, and transient symptoms, and to evaluate the role of earlier food-related symptoms and immunoglobulin E (IgE)-mediated sensitization for the OFC outcome. The OFC resulted in an immediate positive reaction in 38% (n = 148) and a delayed positive reaction in 21% (n = 81) of the 391 children. Transient reactions, the majority of which were localized skin reactions, were seen in almost third (n = 50) of the patients with a negative OFC result (n = 162/391). Immediate localized skin reactions were more common during the milk challenge (p = 0.010), whereas immediate lower respiratory tract symptoms (p = 0.001) were more common during the wheat challenge. Although 14% (n = 21) of those with an immediate ...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
